Introducing Transthyretin as a Differentially Expressed Protein in Washing Subtype of Obsessive-Compulsive Disorder

Basic and Clinical Neuroscience

ARTICLE

Zamanian Azodi, Mona¹  Rezaei Tavirani, Mostafa¹  Arefi Oskouie, Afsaneh¹  Mansouri, Vahid¹  Hamdieh, Mostafa²  Nejati, Naser¹  Hamidpour, Mohsen¹  Ahmadzadeh, Alireza¹  Rostami-Nejad, Mohammad³  Rezaei Tavirani, Majid⁴  Mortazavi Tabatabaei, Seyed Abdolreza¹ 

[1] Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences;Department of Psychology, School of Medicine, Shahid Beheshti University of Medical Sciences;Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences;Department of Surgery, School of Medicine, Iran University of Medical Sciences

关键词: Obsessive-Compulsive Disorder (OCD);    Washing subtype;    Fluoxetine;    Transthyretin (TTR);    Two-Dimensional gel Electrophoresis (2DE);    PPI network analysis;   

DOI  :  10.29252/nirp.bcn.9.3.187

来源: Iran University of Medical Sciences

【 摘 要 】

Introduction: Obsessive-Compulsive Disorder (OCD) as one of the important mental problems is valuable topic for proteomic research studies to better understand the underlying mechanisms of this disorder. Methods: In this paper, gel-based proteomic was used to investigate the proteome profile of 16 female patients with OCD, washing subtype before and after treatment with fluoxetine and comparing them with 20 healthy female controls. Results:One of the abnormally expressed protein spots in this study was introduced and examined for protein-protein interaction network analysis via Cytoscape and its plug-ins. Transthyretin (TTR) protein showed significant expression changes (fold change=1.7, P<0.05). While the expression level of TTR is significantly decreased in OCD patients before any treatments, the trend is partially normalized after treatment with fluoxetine in positive responders. Furthermore, TTR interaction profile shows that the proteins interacting with this protein may get affected as this protein expression trend changes in OCD patients. Conclusion: TTR can be considered for further studies to be validated as a potential biomarker for OCD.

【 授权许可】

Unknown