Effect of Gallic Acid on Dementia Type of Alzheimer Disease in Rats: Electrophysiological and Histological Studies

Basic and Clinical Neuroscience

ARTICLE

Hajipour, Somayeh¹  Sarkaki, Alireza¹  Farbood, Yaghoob¹  Eidi, Akram²  Mortazavi, Pejman³  Valizadeh, Zohreh⁴ 

[1] Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences;Department of Biology, Science & Research Branch, Islamic Azad University;Department of Pathology, Faculty of Specialized Veterinary Science, Science & Research Branch, Islamic Azad University;Department of Nursing and Midwifery, Dezfoul Branch, Islamic Azad University

关键词: Alzheimer disease;    Beta-amyloid;    Long-term potentiation;    Neuronal apoptosis;    Rat;   

DOI  :  10.15412/J.BCN.03070203

来源: Iran University of Medical Sciences

【 摘 要 】

Introduction: To study the effect of gallic acid (GA) on hippocampal long-term potentiation (LTP) and histological changes in animal model of Alzheimer disease (AD) induced by betaamyloid (Aβ). Methods: Sixty-four adult male Wistar rats (300±20 g) were divided into 8 groups: 1) Control (Cont); 2) AD; 3) Sham; 4-7) AD+GA (50, 100, and 200 mg/kg for 10 days, orally) or vehicle, 8) Cont+GA100, Aβ (1μg/μL in each site) was infused into hippocampus bilaterally. Changes of amplitude and slope of LTP induced in hippocampal dentate gyrus (DG) were evaluated by high frequency stimulation (HFS) of perforant path (PP). Results: Data showed that LTP amplitude and area under curve significantly impaired in AD rats (P<0.001), while significantly improved in AD rats treated with GA (P<0.05, P<0.01). Conclusion: Current findings suggest that GA reduces neural damage and brain amyloid neuropathology and improves cognitive function via free radicals scavenging and inhibiting oligomerization of Aβ but with no effect on healthy rats.

【 授权许可】

Unknown