Liver Involvement in Iranian Children With Cystic Fibrosis: Ultrasonography and Biochemical Findings

Journal of Comprehensive Pediatrics

ARTICLE

Najafi, Mehri¹  Najmi Varzaneh, Farnaz²  Khatami, Gholamreza¹  Khodadad, Ahmad¹  Fallahi, Gholamhossein¹  Farahmand, Fatemeh¹  Motamed, Farzaneh¹  Mehdizadeh, Mehrzad¹  Alizadeh, Houman¹  Rezaei, Nima¹  Shoaran, Maryam¹ 

[1] Department of Pediatrics, Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences;Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences;Molecular Immunology Research Center, and Department of Immunology, School of Medicine, Tehran University of Medical Sciences

关键词: Children;    Ultrasonography;    Cystic Fibrosis;    Liver Disease;   

DOI  :  10.17795/compreped-7304

来源: Kowsarmedical

【 摘 要 】

Background: Liver disease is increasingly common in pediatric cystic fibrosis (CF). Liver dysfunction in CF patients is an early complication and relatively common which may progress silently. Objectives: The purpose of this study was to determine the prevalence of abnormal liver architecture by Ultrasonography (US) and their associations to abnormal liver function tests particularly abnormal Gamma Glutamyl Transpeptidase (GGT), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) level for its early detection before the complications occur. Patients and Methods: This study as a cross-sectional study was performed at the Children's Medical Center Hospital, Pediatrics Center of Excellence in Tehran, Iran. In all, 114 patients with cystic fibrosis (70 boys, 44 girls) were enrolled. Sample blood test including AST, ALT, GGT and abdominal Sonography was obtained from all patients. Abnormal liver function test was defined by two consecutive occasions; ALT and/or AST levels were ≥ 2 times the upper limit of normal values. GGT normal values were defined by patient age. Data were analyzed using χ2 test and independent T test. Statistical significance was defined as P values of < 0.05 by SPSS ver.19 software. Results: Abnormal liver function test was detected in CF patients. As well, liver sonogram was abnormal in approximately one-third of the patients. This study showed a higher prevalence of biochemical abnormality in patients with abnormal livers ultrasonography. Conclusions: Noninvasive paraclinical evaluation methods could be recommended in the patients with CF for early detection of silent liver abnormalities before progression to end stage liver disease.

【 授权许可】

Unknown