Association between Takayasu arteritis and ischemic heart disease: a cohort study

Mediterranean Journal of Rheumatology

ARTICLE

Mathilde Versini¹  Shmuel Tiosano²  Kassem Sharif²  Naim Mahroum²  Abdulla Watad²  Doron Comaneshter⁵  Guy Shalom⁶  Yehuda Shoenfeld³  Arnon D. Cohen⁵  Howard Amital⁹ 

[1] Department of Internal Medicine, Archet-1 Hospital, University of Nice-Sophia-Antipolis;Department of Medicine ‘B’, Sheba Medical Center;Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center;Sackler Faculty of Medicine, Tel-Aviv University;Department of Quality Measurements and Research, Chief Physician’s Office, Clalit Health Services;Faculty of Health Sciences, Ben-Gurion University of the Negev;Department of Dermatology and Venereology, Soroka Medical Center;Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev;Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, IRCCS

关键词: Takayasu arteritis;    ischemic heart disease;    vasculitis;    immune diseases;   

DOI  :  10.31138/mjr.30.3.171

学科分类：社会科学、人文和艺术（综合）

来源: PCO Convin S.A.

【 摘 要 】

Purpose of the study: Takayasu arteritis (TA) is an idiopathic large vessel vasculitis, which involves the aorta and its major branches. Our aim was to examine the association between TA and the development of ischemic heart disease (IHD) and its impact on survival. Study design: Using data from Clalit Health Services (CHS), the largest Health Maintenance Organization (HMO) in Israel, the proportion of IHD was compared between patients diagnosed with TA and age- and gender-matched controls. Chi-square and t-tests were used for univariate analysis, and a logistic regression model was employed for multivariate analysis. Survival analysis was performed using Kaplan-Meier plots and cox regression. Results: The study included 155 TA patients and 755 age- and gender-frequency matched controls. The proportion of IHD in TA patients was increased in comparison with controls (32.3% and 8.9%, p<0.001). In multivariate analysis, IHD was associated with TA (OR=6.576, 95% CI: 4.09-10.64) and male gender (OR=2.29, 95% CI: 1.43-4.26). Survival analysis over 15 years of follow-up showed a higher proportion of all-causes mortality in the TA group. In a multivariate analysis, TA (HR=2.58, 95%CI: 1.64-4.06) and IHD (HR=1.64, 95%CI: 1.05-2.55) were found to be associated with reduced survival. Conclusions: TA patients present an increased proportion of IHD, and a reduced 15-years survival rate compared to controls.

【 授权许可】

CC BY-NC