Early Effects of P-15 on Human Bone Marrow Stem Cells

eJournal of Oral Maxillofacial Research

article

Vincenzo Sollazzo¹  Annalisa Palmieri²  Ambra Girardi²  Francesca Farinella³  Francesco Carinci³ 

[1] Orthopedic Clinic, University of Ferrara;Department of Histology, University of Bologna;Department of Maxillofacial Surgery, University of Ferrara

关键词: stem cells;    biomaterial;    P-15;    differentiation;    bone;   

DOI  :  10.5037/jomr.2010.1104

学科分类：社会科学、人文和艺术（综合）

来源: Stilus Optimus

【 摘 要 】

Peptide-15 (P-15) is an analogue of the cell binding domain of collagen. P-15 has been shown to facilitate physiological to process in a way similar to collagen, to serve as anchorage for cells, and to promote the binding, migration and differentiation of cells. However, how P-15 alters osteoblast activity to promote bone formation is poorly understood. To study the osteoinductive properties of peptide P-15, we analyzed the expression levels of bone related genes in human mesenchymal stem cells treated with this biomaterial.

【 授权许可】

CC BY-NC-ND