Epigenetic Changes in Asthma: Role of DNA CpG Methylation

Tuberculosis and Respiratory Diseases

article

Da-Jeong Bae¹  Ji Ae Jun¹  Hun Soo Chang²  Jong Sook Park³  Choon-Sik Park³ 

[1] Department of Interdisciplinary Program in Biomedical Science Major, Soonchunhyang Graduate School;Department of Environmental Health Sciences, Soonchunhyang University;Division of Allergy and Respiratory Medicine, Genome Research Center, Soonchunhyang University Bucheon Hospital

关键词: Asthma;    Gene;    Environment;    Aspirin;    Epigenesis;   

DOI  :  10.4046/trd.2018.0088

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

For the past three decades, more than a thousand of genetic studies have been performed to find out the genetic variants responsible for the risk of asthma. Until now, all of the discovered single nucleotide polymorphisms have explained genetic effects less than initially expected. Thus, clarification of environmental factors has been brought up to overcome the ‘missing’ heritability. The most exciting solution is epigenesis because it intervenes at the junction between the genome and the environment. Epigenesis is an alteration of genetic expression without changes of DNA sequence caused by environmental factors such as nutrients, allergens, cigarette smoke, air pollutants, use of drugs and infectious agents during pre- and post-natal periods and even in adulthood. Three major forms of epigenesis are composed of DNA methylation, histone modifications, and specific microRNA. Recently, several studies have been published on epigenesis in asthma and allergy as a powerful tool for research of genetic heritability in asthma albeit epigenetic changes are at the starting point to obtain the data on specific phenotypes of asthma. In this presentation, we mainly review the potential role of DNA CpG methylation in the risk of asthma and its sub-phenotypes including nonsteroidal anti-inflammatory exacerbated respiratory diseases.

【 授权许可】

CC BY-NC