Systemic White Blood Cell Count as a Biomarker Associated with Severity of Chronic Obstructive Lung Disease

Tuberculosis and Respiratory Diseases

article

Hyeon-Kyoung Koo¹  Hyung Koo Kang¹  Pamela Song²  Hye Kyeong Park¹  Sung-Soon Lee¹  Hoon Jung¹ 

[1] Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inje University Ilsan Paik Hospital, Inje University College of Medicine;Department of Neurology, Inje University Ilsan Paik Hospital, Inje University College of Medicine

关键词: Pulmonary Disease;    Chronic Obstructive;    Leukocyte Count;    Respiratory Function Tests;    Quality of Life;   

DOI  :  10.4046/trd.2017.80.3.304

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Background Chronic obstructive pulmonary disease (COPD), is a chronic inflammatory disorder. We evaluated whether white blood cell (WBC) count, is associated with the severity of COPD, independent of other inflammatory conditions, such as metabolic syndrome. Methods The WBC counts were compared between 1227 COPD patients and 8679 non-COPD adults older than 40. The relationships between the WBC count, lung function, and symptoms score in COPD patients, were determined, using general linear regression analyses. Results The WBC count was negatively associated with forced vital capacity (FVC, L), FVC (% predicted), forced expiry volume in one second (FEV 1 , L), and FEV 1 (% predicted) in COPD patients. Additionally, the WBC count was independently associated with the quality of life measure, by EQ5D-index score. However, this relationship between WBC count, and disease severity, was not significant in current smokers, because of the confounding effect of smoking, on the WBC count. Conclusion The WBC count is associated with current smoking status and COPD severity, and a risk factor for poor lung function, and quality of life, especially in non-currently smoking COPD patients. The WBC count can be used, as an easily measurable COPD biomarker.

【 授权许可】

CC BY-NC