A Case of Statin-Induced Interstitial Pneumonitis due to Rosuvastatin

Tuberculosis and Respiratory Diseases

article

Se Yong Kim¹  Se Jin Kim¹  Doran Yoon²  Seung Wook Hong²  Sehhoon Park²  Chan-Young Ock² 

[1] Department of Internal Medicine, The Armed Forces Medical Hospital;Department of Internal Medicine, Seoul National University Hospital

关键词: Rosuvastatin;    Lung Diseases;    Interstitial;    Chemically-Induced Disorders;   

DOI  :  10.4046/trd.2015.78.3.281

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Statins lower the hyperlipidemia and reduce the incidence of cardiovascular events and related mortality. A 60-year-old man who was diagnosed with a transient ischemic attack was started on acetyl-L-carnitine, cilostazol, and rosuvastatin. After rosuvastatin treatment for 4 weeks, the patient presented with sudden onset fever, cough, and dyspnea. His symptoms were aggravated despite empirical antibiotic treatment. All infectious pathogens were excluded based on results of culture and polymerase chain reaction of the bronchoscopic wash specimens. Chest radiography showed diffuse ground-glass opacities in both lungs, along with several subpleural ground-glass opacity nodules; and a foamy alveolar macrophage appearance was confirmed on bronchoalveolar lavage. We suspected rosuvastatin-induced lung injury, discontinued rosuvastatin and initiated prednisolone 1 mg/kg tapered over 2weeks. After initiating steroid therapy, his symptoms and radiologic findings significantly improved. We suggest that clinicians should be aware of the potential for rosuvastatin-induced lung injury.

【 授权许可】

CC BY-NC