Bilateral Ovarian Metastases from ALK Rearranged Non-Small Cell Lung Cancer

Tuberculosis and Respiratory Diseases

article

Kyung Ann Lee¹  Jong Sik Lee¹  Jae Ki Min¹  Hee Joung Kim¹  Wan Seop Kim²  Kye Young Lee¹ 

[1] Department of Internal Medicine, Konkuk University School of Medicine;Department of Pathology, Konkuk University School of Medicine

关键词: Anaplastic Lymphoma Kinase;    Carcinoma;    Non-Small-Cell Lung;    Neoplasm Metastasis;    Ovary;   

DOI  :  10.4046/trd.2014.77.6.258

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Anaplastic lymphoma kinase ( ALK ) rearrangement, is a kind of driver mutation, accounts for 3%-5% of non-small cell lung cancer (NSCLC). NSCLC patients harboring ALK fusion genes have distinct clinical features and good response to ALK inhibitors. Metastasis from lung cancer to the ovary has rarely been known. We report a case of a 54-year-old woman with bilateral ovarian metastases from ALK rearranged NSCLC. She underwent bilateral salpingo-oophorectomy for ovary masses, which were progressed after cytotoxic chemotherapy although primary lung mass was decreased. Histopathological examination of the ovary tumor showed characteristic adenocarcinoma patterns of the lung and ALK rearrangement.

【 授权许可】

CC BY-NC