Annual Change in Pulmonary Function and Clinical Characteristics of Combined Pulmonary Fibrosis and Emphysema and Idiopathic Pulmonary Fibrosis: Over a 3-Year Follow-up

Tuberculosis and Respiratory Diseases

article

Yu Jin Kim¹  Seong Hyun Shin²  Jeong-Woong Park¹  Sun Young Kyung¹  Shin Myung Kang¹  Sang-Pyo Lee¹  Yon Mi Sung³  Yoon Kyung Kim³  Sung Hwan Jeong¹ 

[1] Division of Pulmonology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon;Gachon University of Medicine and Science, Gachon University Gil Medical Center, Incheon;Department of Radiology, Gachon University Gil Medical Center, Incheon

关键词: Pulmonary Emphysema;    Pulmonary Fibrosis;    Idiopathic Pulmonary Fibrosis;    Respiratory Function Tests;   

DOI  :  10.4046/trd.2014.77.1.18

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Background Combined pulmonary fibrosis and emphysema (CPFE) have different pulmonary function tests (PFTs) and outcomes than idiopathic pulmonary fibrosis (IPF). The intention of this study was to identify unknown differences between CPFE and IPF by a retrospective comparison of clinical data including baseline and annual changes in pulmonary function, comorbidities, laboratory findings, clinical characteristics and cause of hospitalization. Methods This study retrospectively enrolled patients with CPFE and IPF who had undergone PFTs once or several times per year during a follow-up period of three years. Baseline clinical characteristics and the annual changes in the pulmonary function during the follow-up period were compared between 26 with CPFE and 42 patients with IPF. Results The baseline ratio of forced expiratory volume in one second to forced vital capacity (FEV 1 /FVC%) in patients with CPFE was lower than that in patients with IPF (78.6±1.7 vs. 82.9±1.1, p=0.041). The annual decrease in FEV 1 /FVC in the CPFE was significantly higher than in the IPF. The annual decreases in diffusion capacity of carbon monoxide and FVC showed no significant differences between the two groups. The symptom durations of cough and sputum were in the CPFE significantly lower than in the IPF. The serum erythrocyte sedimentation rate level at the acute stage was significantly higher than in the IPF. There were no significant differences in the hospitalization rate and pneumonia was the most common cause of hospitalization in both study groups. Conclusion The annual decrease of FEV 1 /FVC was in patients with CPFE significantly higher than in the patients with IPF.

【 授权许可】

CC BY-NC