Outcomes of Second-Line Chemotherapy for Advanced Non-Small Cell Lung Cancer in One Institution

Tuberculosis and Respiratory Diseases

article

Seok Jeong Lee¹  Hyun Ju Kang¹  Seo Woo Kim¹  Yon Ju Ryu¹  Jin Hwa Lee¹  Yookyung Kim²  Jung Hyun Chang¹ 

[1] Department of Internal Medicine, Ewha Womans University School of Medicine;Department of Radiology, Ewha Womans University School of Medicine

关键词: Age Groups;    Carcinoma;    Non-Small-Cell Lung;    Drug Therapy;    Survival;   

DOI  :  10.4046/trd.2014.77.1.13

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Background This study analyzed the negative prognostic factors in patients who received second-line chemotherapy for advanced inoperable non-small cell lung cancer (NSCLC). Methods We retrospectively reviewed the records of 137 patients with inoperable stage III-IV NSCLC who received second-line chemotherapy. The effects of clinical parameters on survival were analyzed and the hazard ratios (HR) for mortality were identified by a Cox regression analysis. Results Sex, age older than 65 years, smoking history, cell type, T-stage, best response to first-line chemotherapy and first-line chemotherapy regimen were significant negative predictors in univariate analysis. The multivariate analysis showed that patients older than 65 years (HR, 1.530; 95% confidence interval [CI], 1.020-2.297), advanced T stage (T4 vs. T1; HR, 2.273; 95% CI, 1.010-5.114) and non-responders who showed progression with first-line chemotherapy (HR, 1.530; 95% CI, 1.063-2.203) had higher HR for death. Conclusion The age factor, T stage and responsiveness to first-line chemotherapy were important factors in predicting the outcome of patients with advanced NSCLC who received second-line chemotherapy. The results may help to predict outcomes for these patients in the future.

【 授权许可】

CC BY-NC