A Case of Acute Pulmonary Thromboembolism after Taking Tadalafil

Tuberculosis and Respiratory Diseases

article

Jinwoo Lee¹  Ji Hyun Kwon²  Chang-Hoon Lee¹  Sang-Min Lee¹  Jae-Joon Yim¹  Chuy-Gyu Yoo¹  Young Whan Kim¹  Sung Koo Han¹  Young Sik Park¹ 

[1] Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Lung Institute, Seoul National University College of Medicine;Department of Internal Medicine, Seoul National University College of Medicine

关键词: Pulmonary Embolism;    Pulmonary Infarction;    Tadalafil;    Phosphodiesterase 5 Inhibitors;    Factor VIII;   

DOI  :  10.4046/trd.2012.73.4.231

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Tadalafil is a phosphodiesterase-5 inhibitor (PDE5I), which is widely used to treat erectile dysfunction. Although PDE5Is have excellent safety profiles, and most of the side effects are mild, rare serious adverse events have been reported in association with PDE5Is. Thrombosis is one of those events, and a few previous reports have suggested the association of PDE5Is with thrombosis. We report the case of a 61-year-old male who developed pulmonary embolism combined with pulmonary infarction directly after taking tadalafil. Both the patient and the physician suspected tadalafil as the culprit drug, as the patient was in an otherwise healthy condition. However, after extensive evaluation, we noticed that factor VIII levels were elevated. Prior reports suggesting the association between thrombosis and PDEIs either lack complete information on coagulation factors, or show inconsistencies in their results. Physicians should operate caution prior to accepting the diagnosis of adverse drug reaction.

【 授权许可】

CC BY-NC