Respiratory Virus Detection Rate in Patients with Severe or Atypical Community-acquired Pneumonia.

Tuberculosis and Respiratory Diseases

article

Park, Ji Won¹  Jung, Sun Young²  Eun, Hyuk Soo²  Cheon, Shinhye²  Seong, Seok Woo²  Park, Dong Il²  Park, Myung Rin²  Park, Hee Sun²  Jung, Sung Soo²  Kim, Ju Ock²  Kim, Sun Young²  Lee, Jeong Eun² 

[1] Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine;Department of Internal Medicine, Chungnam National University College of Medicine

关键词: Viruses;    Pneumonia;    Polymerase Chain Reaction;   

DOI  :  10.4046/trd.2011.71.5.335

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

BACKGROUND Community-acquired pneumonia (CAP) is an important cause of morbidity and mortality throughout the world in all age groups. Viral causes of CAP are less well characterized than bacterial causes. We analyzed the characteristics of hospitalized patients with CAP who had a viral pathogen detected by multiplex polymerase chain reaction (PCR). METHODS: Multiplex real-time PCR was performed for respiratory viruses in samples collected from 520 adults who developed CAP at Chungnam National University Hospital. Clinical, laboratory, and radiological features at presentation as well as other epidemiological data were analyzed. RESULTS: Of 520 patients with CAP, a viral pathogen was detected in 60 (11.5%), and influenza A was the most common. The virus detection rate in patients with CAP was highest in November. Two or more pathogens were detected in 13 (21.7%) patients. Seven patients had severe disease and were administered in the intensive care unit. Most patients (49/60, 81.7%) had comorbidities. However, nine (15%) patients had no comorbidities, and their age was <60 years. The ground glass opacity pattern was the most common radiological feature. Seven (11.7%) patients died from CAP. CONCLUSION: Viral pathogens are commonly detected in patients with CAP, and a respiratory virus may be associated with the severity and outcome of pneumonia. Careful attention should be paid to the viral etiology in adult patients with CAP.

【 授权许可】

CC BY-NC