Usefulness of Serum Cortisol in Assessment for the Severity of Community-Acquired Pneumonia.

Tuberculosis and Respiratory Diseases

article

Kim, Min Su¹  Park, Hun Pyo¹  Yoon, Kyung Hwa¹  Kim, Yeon Jae²  Kim, Mi Young²  Kim, Eun Young²  Bae, Myoung Nam³  Bae, Sang Mook³ 

[1] Department of Internal Medicine, Daegu Fatima Hospital;Department of Internal Medicine, The Catholic University of Korea College of Medicine;Department of Respiratory Medicine, Changwon Fatima Hospital

关键词: Community acquired infections;    Pneumonia;    Cortisol;    Severity of Illness Index;    CURB-65;   

DOI  :  10.4046/trd.2010.69.6.450

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

BACKGROUND High cortisol levels are frequently observed in patients with severe infections are of prognostic value in sepsis. The aim of this study was to evaluate the clinical usefulness of serum cortisol in assessment for the severity of community-acquired pneumonia (CAP). METHODS: This study analyzed the results of 52 CAP subjects admitted in Changwon Fatima Hospital between July 2008 to May 2010. Total serum cortisol, infection markers such as C-reactive protein (CRP), procalcitonin (PCT) and CURB (Confusion, Uremia, Respiratory rate, Blood pressure)-65 were examined retrospectively. RESULTS: In clinically unstable subjects on admission day 4, baseline serum cortisol, CURB-65, and CRP were elevated significantly compared to those of stable subjects. Area under curve (AUC) of cortisol, CRP, and CURB-65 from ROC curves were 0.847, 0.783, and 0.724 respectively. In the subjects with serum cortisol > or =22.82 microg/dL, CRP, PCT, CURB-65 score, and mortality were significantly elevated. CONCLUSION: These findings suggest that measurement of serum cortisol in early stage may provide helpful information in the assessment of CAP severity.

【 授权许可】

CC BY-NC