Bronchiolitis Obliterans Organizing Pneumonia in the Patient with Non-Small Cell Lung Cancer Treated with Docetaxel/Cisplatin Chemotherapy: A Case Report.

Tuberculosis and Respiratory Diseases

article

Kim, Ae Ran¹  Kim, Tae Young²  Lee, Young Min²  Lee, Seung Heon²  Jung, Soo Jin³  Lee, Hyun Kyung² 

[1] Department of Internal Medicine, Daedong Hospital, Pusan Paik Hospital, Inje University College of Medicine;Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine;Department of Pathology, Pusan Paik Hospital, Inje University College of Medicine

关键词: Cryptogenic Organizing Pneumonia;    Docetaxel;    Lung Neoplasms;    Drug Therapy;   

DOI  :  10.4046/trd.2010.69.4.293

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

A 60-year-old man was diagnosed with stage IV squamous cell carcinoma of lung and treated with weekly doses of docetaxel and cisplatin. Tumor mass and mediastinal lymphadenopathy disappeared after 4.5 cycles of chemotherapy. At one week post final chemotherapy, the patients developed sudden shortness of breath. New, multifocal infiltrations developed on both lungs without definitive evidence of infection. Despite administration of broad spectrum antibiotics, the lung lesion did not improve, so bronchoalveolar lavage and computed tomography-guided lung biopsy were performed. The proportion of lymphocytes was increased markedly and histopathology revealed squamous cell carcinoma combined with bronchiolitis obliterans organizing pneumonia. After high dose corticosteroid therapy, dyspnea and the newly developed consolidation had decreased slightly. However, dyspnea and hypoxemia increased again because of aggravated lung cancer since chemotherapy had stopped. Chemotherapy couldn’t be restarted due to the poor performance status of the patient. Later, patient died of respiratory failure from poor general condition and progression of lung cancer.

【 授权许可】

CC BY-NC