A Case of Delayed Severe Hypersensitivity Reaction during Genexol-PM(R) Infusion.

Tuberculosis and Respiratory Diseases

article

Kim, Hyun Kyung¹  Kim, Su Woo¹  Kang, Hye Won¹  Kwon, Kyoung Joo¹  Park, Hye Sung¹  Ryu, Yon Ju¹  Lee, Jin Hwa¹  Chun, Eun Mi¹  Cho, Young Joo¹  Chang, Jung Hyun¹ 

[1] Department of Internal Medicine, Ewha Womans University School of Medicine

关键词: Hypersensitivity;    Delayed;    Anaphylaxis;    Purpura;    Paclitaxel;   

DOI  :  10.4046/trd.2010.68.5.294

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Although Taxol(R) is one of the most successful drugs in current cancer chemotherapy against solid tumors, a major problem is hypersensitivity reactions that arises as a consequence of activation of the complement (C) system, "C activation-related pseudo-allergy". Most severe hypersenstivity reactions occur within the first few minutes of Taxol(R) administration, usually after the first or second dose. Here we report a case of a severe hypersensitivity reaction in a 72-year-old man undergoing Genexol-PM(R) infusion. Hypotension and polymorphic pruritic skin rash appeared 2 hours after the start of Genexol-PM(R) infusion (with an appropriate premedication). Treating with methylprednisolone, epinephrine and inotropic agents, reduced the hypotension and the skin rash disappeared. We report this case with a review of the literature.

【 授权许可】

CC BY-NC