Gut Microbiota and its Role in Immune Response to Helminth Infections

International Journal of Enteric Pathogens

article

Mohammad Zibaei¹ 

[1] Department of Parasitology and Mycology, School of Medicine, Alborz University of Medical Sciences

关键词: Helminth;    symbiotic;    microbiota;    cytokine;   

DOI  :  10.15171/ijep.2017.16

学科分类：农业科学（综合）

来源: Alborz University of Medical Sciences

【 摘 要 】

The microbiota is an ecological community of commensal, symbiotic, and pathogenic microorganisms. 1 The gut microbiota has evolved as a new important player in the pathophysiology of many intestinal diseases. Recently, special interest has been arisen on gut microbiota-host interaction because extensive evidence has shown that intestinal microbiota composition has an important role in human health and disease such as infectious diseases. Dysbiosis of the microbiota has been related to a plethora of infections and still increasing number of diseases. Studies have mostly focused on analyzing the associations between disease and an aberrant microbiota composition. 2 Generally, the Th2 lymphocytes response is accepted as the responsible mechanism for most striking clinical features in helminth infection. The Th2 response results in the production of IL-4 (helps B cells switch from an IgM response to IgG, IgA, and, more importantly, IgE), IL-5 (an eosinophilopoietic cytokine), and IL-13 (associated with the hyper-reactivity of the asthmatic lung).3,4 One of the most physiological functions that is affected by the composition of the microbiota is immune responses, but it has not been clearly demonstrated if these immune effects can occur in the absence of gut bacteria. Therefore, it is possible that certain elements of immune regulation by helminths is caused by alterations to the bacterial communities of the host.

【 授权许可】

CC BY-NC