Evaluation of Reciprocal Pharmaceutical Effects and Antibacterial Activity of Silver Nanoparticles and Methanolic Extract of Crocus sativus L. (Saffron) on Some Bacterial Strains

International Journal of Enteric Pathogens

article

Anahita Samiee Zafarghandi¹  Hamid Reza Ahmadi Ashtiani¹  Seyyed Mahdi Rezayat²  Neda Soleimani³  Seyyed Reza Hosseini Doost¹  Shabnam Heydarzadeh Khoyi¹ 

[1] Islamic Azad University, Pharmaceutical Sciences Branch;Department of Pharmacology, School of Medicine, Islamic Azad University, Pharmaceutical Sciences Branch;Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University

关键词: Silver nanoparticles;    Saffron extract;    Antibacterial effects;    MRSA;   

DOI  :  10.15171/ijep.2017.05

学科分类：农业科学（综合）

来源: Alborz University of Medical Sciences

【 摘 要 】

Background: Silver nanoparticles (Ag-NPs) are the most prominent nanoparticles which are recognized for their high antimicrobial efficacy. Objectives: The aim of this study was to evaluate the reciprocal pharmaceutical effects and antibacterial activity of Ag-NPs and methanolic extract of Crocus sativus L. (saffron) on some bacterial strains. Materials and Methods: For evaluation of antibacterial activity of Ag-NPs and methanolic extract of C. sativus L. (saffron) on some bacteria, agar well diffusion method was used. Minimal inhibition concentration (MIC) and minimum bactericidal concentration (MBC) were determined for saffron extract, Ag-NPs, and their combination on methicillin-resistant Staphylococcus aureus (MRSA) and S. pyogenes and S. epidermidis. Results: The combination of medium concentrations of Ag-NPs (500 μg/mL) and saffron extract (50 mg/mL) was in the optimum mode to eliminate S. epidermidis and S. pyogenes. The results showed that saffron extract, Ag-NPs, and their combined form had antibacterial effects on these bacteria. Conclusion: It is suggested to evaluate the synergistic effects of active components of the extract and antimicrobial preservatives used in food, health, pharmaceutical, and cosmetic industries.

【 授权许可】

CC BY-NC