Right versus left-sided colon cancer: Is it time to consider these as different diseases?

AIMS Medical Science

article

Paul J Ross¹  Krishnie Srikandarajah¹  Julien de Naurois¹ 

[1] Guy’s Cancer Centre, Guy’s and St Thomas’ NHS Foundation Trust, Management Offices

关键词: primary tumour location;    metastatic colorectal cancer;    sidedness;    prognostic;    predictive;    molecular signature;    stratification;    ;   

DOI  :  10.3934/medsci.2018.3.303

来源: American Institute of Mathematical Sciences

【 摘 要 】

Primary tumour location has emerged as an important characteristic in understanding the outcomes for patients with colorectal cancer. Recent international re-appraisal of randomised controlled data as well as case series and epidemiological databases clearly demonstrate that primary tumour location is both an independent prognostic marker and has predictive value in relation to anti-EGFR therapy. Consequently, location should be taken into consideration in the clinical management of patients affected by colon cancer as well as informing research and the design of future clinical trials.

【 授权许可】

CC BY