Pharmacokinetic interaction of tulathromycin with Flunixin meglumine after intravenous injection in goats

Journal of Veterinary Medical Research

article

Adam, M.¹  Tohamy, M. A.¹  El-Sadek, S.E.¹  M. Radi, Abeer¹ 

[1] Pharmacology Department, Faculty of Veterinary Medicine, Beni-Suef University

关键词: Pharmacokinetics;    Tulathromycin;    Flunixin;    intravenous;    goats;   

DOI  :  10.21608/jvmr.2016.43241

学科分类：社会科学、人文和艺术（综合）

来源: Beni-Suef University

【 摘 要 】

The pharmacokinetic aspects of tulathromycin (2.5 mg/kg b.w.) were studied following intravenous administration alone and in combination with flunixin meglumine (2.2 mg/kg b.w) in apparently healthy goats. Tulathromycin concentrations in serum were determined by microbiological assay technique using Bacillus subtiles (ATCC 66343) as test organism. The half-lives of distribution and elimination (t 0.5(α)and t 0.5(β)) were 0.071, 0.046 and 6.43, and 5.05 h. following intravenous injection of tulathromycin alone and in combination with flunixin, respectively. Volume of distribution at steady state (Vdss) was 0.249 and 0.96l/kg., mean residence time (MRT) was 6.27 and 5.99 h and total body clearance (ClB) was 0.046 and 0.17 l/kg/hr., respectively. It was concluded that flunixin significantly altered the pharmacokinetics of tulathromycin by increase its distribution and accelerate its elimination from body. Therefore care should be taken during use of tulathromycin in goats concurrently with flunixin.

【 授权许可】

CC BY