Warfarin Induced Necrosis of The Breast: A Case Report

Archives of Breast Cancer

article

Sanaz Zand¹  Roghayye Jalili²  Seyed Hasan Emami Razavi³  Massoome Najafi³  Ahmad Kaviani⁴ 

[1] Department of Research, Kaviani Breast Disese Institute (KBDI);Department of Surgery, Tehran University of Medical Sciences;Department of Surgery, Tehran University of Medical Sciences(TUMS), Iran AND International Center for Surgical Safety (ICSS), St. Michael Hospital, University of Toronto;Department of Surgery, Tehran University of Medical Sciences, Iran AND Department of Research, Kaviani Breast Diseases Institute

关键词: Warfarin;    breast necrosis;    breast gangrene;    oral anticoagulant therapy;   

DOI  :  10.32768/abc.201854189-191

学科分类：社会科学、人文和艺术（综合）

来源: Kaviani Breast Disease Institute

【 摘 要 】

Background: Warfarin induced breast necrosis is a rare complication of oral anticoagulant therapy. Although it can be related to protein C, S, and antithrombin III deficiency; the pathogenesis of necrosis is still unknown. Case presentation: We report a case of a 38-year-old woman with extensive left breast necrosis after receiving warfarin for treatment of deep vein thrombosis. Simple mastectomy was performed and the wound was closed secondarily with an abdominal advancement flap. Rivaroxaban was prescribed after discontinuation of warfarin. Conclusion: Although breast necrosis following warfarin usage is uncommon, it should be considered in women presenting with breast symptoms after initiation of warfarin. Early diagnosis and appropriate management are essential to prevent extensive loss of breast tissue.

【 授权许可】

CC BY-NC