Comparison of Clinicopathological Characteristics and Outcome of Inflammatory and Non-inflammatory Locally Advanced Breast Cancer: A Study in Iran

Archives of Breast Cancer

article

Saeed Arefanian¹  Neda Mehradad²  Shahpar Haghighat²  Safa Najafi²  Mandana Ebrahimi²  Asiie Olfatbakhsh² 

[1] Department of Surgery, Washington University;Breast Disease Research Group, Breast Cancer Research Center

关键词: Survival;    clinicopathological characteristic;    inflammatory breast cancer;    locally advanced breast cancer;    ;   

DOI  :  10.19187/abc.20141115-19

学科分类：社会科学、人文和艺术（综合）

来源: Kaviani Breast Disease Institute

【 摘 要 】

Background: Inflammatory breast cancer ( ), a subgroup of locally IBC advanced breast cancer ( ), is diagnosed based on clinical findings, and LABC seems to be different from other types of . The purpose of this study was to LABC compare clinicopathological characteristics and outcomes between inflammatory and non-inflammatory patients at Breast Cancer Research Center ( ), LABC BCRC Tehran, Iran. Mehods: The medical records of all patients who were diagnosed as in LABC BCRC since 1997 to 2011 were extracted from the database. Then, clinical and pathological characteristics and overall survival of patients were compared IBC with non-inflammatory ( - ). LABC NI LABC Results: A total number of 340 patients were identified as from which LABC 17 patients (5%) were diagnosed as . Menopausal status, body mass index IBC ( ), family history of breast cancer, nodal status, and Her2/neu and BMI PR positivity were not statistically different between and - groups. The IBC NI LABC difference in estrogen receptor ( ) between the two groups was significant (P = ER 0.028). Median duration of follow-up was 26.50 months. Patients with had IBC overall survival of 27.9 months (95% : 22.7–33.1) which was lower than CI patients in the - group with a survival of 118.9 months (95% : 107.3- NII LABC CI 130.6) (P = 0.015). The difference between the disease-free survivals of the two groups were also statistically significant (P< 0.001). Conclusions: Compared to - , is more frequently negative NI LABC IBC ER and more commonly associated with lower survival rate. These findings reinforce the idea that has a more aggressive biology and more unfavorable outcome IBC than - and needs close follow-up.

【 授权许可】

CC BY-NC