Clinical data analysis reveals the role of OGR1 (GPR68) in head and neck squamous cancer

Animal Models and Experimental Medicine

article

Wenlong Zhang¹  Yong Han³  Weisha Li¹  Lin Cao¹  Libo Yan¹  Chuan Qin¹  Ran Gao¹ 

[1] Key Laboratory of Human Disease Comparative Medicine (National Health and Family Planning Commission), The Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases;Department of Pathology, Zhejiang Provincial People’s Hospital;People’s Hospital of Hangzhou Medical College;Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province

关键词: head and neck squamous cancer (HNSC);    OGR1;    TCGA;    UALCAN;   

DOI  :  10.1002/ame2.12105

学科分类：机械工程学

来源: Wiley

【 摘 要 】

Background: Head and neck squamous cancer (HNSC) frequently occurs in the clinic. Revealing the role of the genes that correlate with cancer cell outgrowth will contribute to potential treatment target identification and tumor inhibition. Methods: The gene expression profiles and gene ontology of the proton-sensing G-protein-coupled receptor OGR1 were analyzed using the TCGA (The Cancer Genome Atlas) database. The effects of sex, age, race, and degree of malignancy on HNSC were investigated, and the survival times of HNSC patients with high or low/ medium expression levels of OGR1 were compared. Methylation of the OGR1 promoter CpG sites was also investigated and OGR1-related genes were analyzed using gene set enrichment analysis. Results: OGR1 is overexpressed in HNSC patients. However, compared with the low/median expression group, the high OGR1 expression group did not have different survival rates. The OGR1 expression level differed across sex, age, race, and degree of malignancy, while the methylation of the OGR1 promoter CpG sites was maintained at a similar level. Gene set enrichment analysis revealed that OGR1 was positively correlated with head and neck cancer, cisplatin resistance, hypoxia, angiogenesis, cell migration, and TGF-β. Conclusion: The expression of OGR1 correlated with HNSC progression and survival and thus can serve as a potential treatment target and prognostic marker.

【 授权许可】

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