Downregulation of HNRNPK in human cancer cells inhibits lung metastasis

Animal Models and Experimental Medicine

article

Mengyuan Li¹  Wenlong Zhang¹  Xingjiu Yang¹  Hongfei Liu¹  Lin Cao¹  Weisha Li¹  Le Wang¹  Guoxin Zhang¹  Ran Gao¹ 

[1] Key Laboratory of Human Disease Comparative Medicine (National Health and Family Planning Commission), The Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases

关键词: HNRNPK;    lung metastasis;    mouse model;   

DOI  :  10.1002/ame2.12090

学科分类：机械工程学

来源: Wiley

【 摘 要 】

Background: Lung cancer frequently occurs in the clinic, leading to poor prognosis and high mortality. Markers for early diagnosis of lung cancer are scarce, and further potential therapeutic targets are also urgently needed. Method: We established a new mouse model in which the specific gene HNRNPK (heterogeneous nuclear ribonucleoprotein K) was downregulated after administration of doxycycline. The lung metastatic nodules were investigated using bioluminescence imaging, micro-CT, and autopsy quantification. Results: Compared with the short hairpin negative control group, less lung metastatic nodules were formed in the short hairpin RNA group. Conclusion: Downregulation of HNRNPK in cancer cells can inhibit lung metastasis.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND