Allantoin attenuates deficits of behavioural and motor nerve conduction in an animal model of cisplatin-induced neurotoxicity in rats

Animal Models and Experimental Medicine

article

Vindya N S¹  Aqib Mohamad¹  Rema Razdan¹ 

[1] Department of Pharmacology, Al-Ameen College of Pharmacy

关键词: allantoin;    cisplatin;    neurotoxicity;    rats;   

DOI  :  10.1002/ame2.12070

学科分类：机械工程学

来源: Wiley

【 摘 要 】

Background: The aim of the present study was to evaluate the neuroprotective ef‐ fect of allantoin in cisplatin‐induced toxicity in rats. Methods: Adult male Wistar rats weighing 160‐200 g were used. Neuropathy was induced by injecting cisplatin (2 mg/kg, ip, twice a week for 6 weeks) and the rats were concurrently treated with allantoin (200 and 400 mg/kg, po) for 8 weeks. At the end of the study, body weight and hemogram were measured. Behavioural tests were performed, including tests for cold and hot hyperalgesia, motor co‐ordination, locomotor activity, mechano‐tactile allodynia and mechanical hyperalgesia. The rats were then sacrificed and sciatic nerve conduction velocity was determined. The anti‐ oxidant enzyme and nitric oxide levels in sciatic nerve homogenates were measured. Results: In this study, allantoin restored the motor nerve conduction velocity defi‐ cits induced by cisplatin, and the allantoin‐treated rats showed improvement in cold and thermal hyperalgesia, mechano‐tactile allodynia, and mechanical hyperalgesia. Allantoin treatment also improved the rats’ hematological status, increasing haemo‐ globin, platelet and RBC counts compared to the cisplatin‐treated group. Allantoin treatment also mitigated the functional abnormalities seen in the cisplatin neuropa‐ thy group, protecting neurons from the neurotoxic effects of cisplatin. Conclusion: Allantoin shows promise for use as an adjuvant drug in cancer treatment to protect against cisplatin‐induced neuropathy.

【 授权许可】

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