Migraine and risk of sudden sensorineural hearing loss: A systematic review and meta-analysis

Laryngoscope Investigative Otolaryngology

article

Masoud Mohammadi¹  Mohammad Hosein Taziki Balajelini³  Abdolhalim Rajabi⁴ 

[1] Medical Library and Information Science, Tehran University of Medical Sciences;Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences;Clinical Research Development Unit (CRDU), Golestan University of Medical Sciences;Environmental Health Research Center, Faculty of Health, Golestan University of Medical Sciences

关键词: migraine;    risk;    sudden sensorineural hearing loss;   

DOI  :  10.1002/lio2.477

学科分类：环境科学（综合）

来源: Wiley

【 摘 要 】

Objective: The pathophysiology of idiopathic sudden sensorineural hearing loss (SSNHL) is poorly understood. This study aimed to explore the association of migraine and risk of SSNHL in a meta-analysis of population-based cohort studies. Methods: A systematic literature search of studies published until December 2019 was carried out in Medline, Embase, Scopus, Web of Science, and Google Scholar using appropriate keywords. References of the retrieved articles were also examined for inclusion. Random-effects meta-analysis was performed by calculating pooled hazard ratio (HR) and associated 95% confidence interval (CI) using the DerSimonian and Laird method while considering conceptual heterogeneity. Results: Three eligible cohort studies, with 282 250 participants, were included. In total, 56 450 had migraine, and 225 800 had no migraine. Of those with migraine, 0.88% had SSNHL, and among those without migraine, 0.59% had SSNHL. Pooled HR for the risk of SSNHL was 1.84 (95% CI: 1.11-2.57; P 40 years old. Conclusions: Individuals with migraine patients are at a higher risk of developing SSHL. Different age and sex migraine subgroups showed a higher proportion of SSNHL cases compared to nonmigraineurs.

【 授权许可】

CC BY|CC BY-NC-ND