The prognostic significance of human papilloma virus in sinonasal squamous cell carcinoma

Laryngoscope Investigative Otolaryngology

article

Emily Schlussel Markovic¹  Kathryn E. Marqueen¹  Kunal K. Sindhu¹  Eric J. Lehrer¹  Jerry Liu¹  Brett Mile²  Eric Genden²  Sonam Sharma¹  Vishal Gupta¹  William Westra³  Alfred Iloreta²  Marshall Posner⁴  Krzysztof Misiukiewicz⁴  Richard L. Bakst¹ 

[1] Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai;Department of Otolaryngology, Icahn School of Medicine at Mount Sinai;Department of Pathology, Icahn School of Medicine at Mount Sinai;Department of Medicine, Division of Hematology/Oncology, Icahn School of Medicine at Mount Sinai

关键词: human papilloma virus (HPV);    prognosis;    sinonasal carcinoma;   

DOI  :  10.1002/lio2.468

学科分类：环境科学（综合）

来源: Wiley

【 摘 要 】

Background: Human papilloma virus (HPV) has been implicated in the pathology of oropharyngeal head and neck cancers, but its role in sinonasal squamous cell carcinoma (SNSCC) has not been well established. Methods: Thirty-two patients with SNSCC diagnosed between 2011 and 2018 were identified and stratified by HPV status and viral serotype, as determined by PCR. Endpoints including recurrence, metastases and survival were analyzed using the Kaplan-Meier method. Results: Seventeen (53%) patients were HPV-positive and 15 (47%) were HPV-negative. The median follow-up time of living patients was 30.7 months (range 4-123 months). Survival did not differ by HPV status, but HPV+ tumors were more likely to locally recur and metastasize. When stratifying by treatment type, the lowest rate of recurrence occurred in patients receiving surgery and chemoradiation. Conclusion: A significant proportion of sinonasal tumors appear to be associated with HPV. Testing for HPV might be justified in all cases of sinonasal cancers. Further investigation is warranted to better understand the role of HPV in SNSCC.

【 授权许可】

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