Study on the 2-Phenylchroman-4-One Derivatives and their anti -MERS-CoV Activities

Bulletin of the Korean Chemical Society

article

Ji Hye Yoon¹  Jihye Lee²  Jun Young Lee¹  Young Sup Shin¹  Dong Eon Kim³  Jung Sun Min³  Chul Min Park¹  Jong Hwan Song¹  Seungtaek Kim²  Sunoh Kwon³  Min Seong Jang⁴  Hyoung Rae Kim¹ 

[1] Center for Convergent Research of Imerging Virus Infection, Korea Research Institute of Chemical Technology;Respiratory Virus Laboratory, Institut Pasteur;Herbal Medicine Research Division, Korea Institute of Oriental Medicine;Department of Non-Clinical Studies, Korea Institute of Toxicology

关键词: MERS-CoV;    anti-MERS;    2-phenylchroman-4-one;    Bavachin;   

DOI  :  10.1002/bkcs.11832

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Middle East respiratory syndrome coronavirus (MERS-CoV) has been one of the most fearful diseases by its mortality and possibility of global outbreak. Until 23 January 2019, 2279 laboratory-confirmed cases of MERS-CoV, including 806 associated deaths (case-fatality rate: 35.5%) were reported globally.1 In Korea on May 2015, 186 confirmed cases including 38 associated deaths (20.4%) were reported by an outbreak caused by only one infected person from Saudi Arabia.2 At present, no effective vaccine or therapeutics are available for the prevention or treatment of MERS-CoV infection.3–5 However, various basic and clinical research are on-going.

【 授权许可】

Unknown