M2b macrophage polarization and its roles in diseases

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Le-xun Wang¹  Sheng-xi Zhang¹  Hui-juan Wu¹  Xiang-lu Rong¹  Jiao Guo¹ 

[1] Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Joint Laboratory of Guangdong, Guangdong Key Laboratory of Metabolic Disease Prevention and Treatment of Traditional Chinese Medicine, Institute of Chinese Medicine Sciences, Guangdong Pharmaceutical University

关键词: Autoimmunity;    Chemokines;    Disease pathogenesis;    Inflammation;    Manipulation of immune response;    Monocyte/Macrophage;   

DOI  :  10.1002/JLB.3RU1018-378RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Macrophages play an important role in a wide variety of physiologic and pathologic processes. Plasticity and functional polarization are hallmarks of macrophages. Macrophages commonly exist in two distinct subsets: classically activated macrophages (M1) and alternatively activated macrophages (M2). M2b, a subtype of M2 macrophages, has attracted increasing attention over the past decade due to its strong immune-regulated and anti-inflammatory effects. A wide variety of stimuli and multiple factors modulate M2b macrophage polarization in vitro and in vivo. M2b macrophages possess both protective and pathogenic roles in various diseases. Understanding the mechanisms of M2b macrophage activation and the modulation of their polarization might provide a great perspective for the design of novel therapeutic strategies. The purpose of this review is to discuss current knowledge of M2b macrophage polarization, the roles of M2b macrophages in a variety of diseases and the stimuli to modulate M2b macrophage polarization.

【 授权许可】

CC BY