The pathogenesis of tuberculous meningitis

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Angharad Grace Davis¹  Ursula Karin Rohlwink⁴  Alizé Proust¹  Anthony A. Figaji⁴  Robert J. Wilkinson¹ 

[1] The Francis Crick Institute;Faculty of Life Sciences, University College London;Department of Medicine, University of Cape Town;Neuroscience Institute, Division of Neurosurgery, University of Cape Town;Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town;Department of Medicine, Imperial College, United Kingdom

关键词: mycobacterial;    endothelial cells;    granulocytes;    microglia cells;    monocytes/macrophages;    myeloid cells;    neutrophils;    T Lymphocytes;    Th17 cells;   

DOI  :  10.1002/JLB.MR0318-102R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM), which represents a medical emergency associated with high rates of mortality and disability. Via various mechanisms the Mycobacterium tuberculosis (M.tb) bacillus disseminates from the primary site of infection and overcomes protective barriers to enter the CNS. There it induces an inflammatory response involving both the peripheral and resident immune cells, which initiates a cascade of pathologic mechanisms that may either contain the disease or result in significant brain injury. Here we review the steps from primary infection to cerebral disease, factors that contribute to the virulence of the organism and the vulnerability of the host and discuss the immune response and the clinical manifestations arising. Priorities for future research directions are suggested.

【 授权许可】

CC BY