Noncoding RNA in NK cells

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Chuan Yang¹  Chongyang Shen²  Ting Feng¹  Hong Li¹ 

[1] Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University;Basic Medicine College, Chengdu University of Traditional Chinese Medicine

关键词: cytokines;    gene regulation mechanism;    immune response;    lncRNA;    microRNA;    NK cell;   

DOI  :  10.1002/JLB.1RU0518-197RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Noncoding RNAs (ncRNA) are important regulators that modulate cell proliferation, apoptosis, the cell cycle, and DNA methylation. NK cells mediate the immune response via the secretion of various cytokines and are important innate immune cells in the human immune system. Recent studies have found that ncRNA plays an important role in NK cell development and function. With recent advances in bioinformatics and next-generation sequencing, novel ncRNAs have been identified, allowing us to more fully appreciate its functions in NK cell biology. In this review, we summarize and discuss the latest studies on the functions and regulatory mechanisms of long noncoding RNA (lncRNA) and microRNA in NK cells from the viewpoint of epigenetic mechanisms to help us clearly understand ncRNA in NK cells.

【 授权许可】

CC BY