The interplay between neutrophils and microbiota in cancer

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Carolyne K. Smith¹  Giorgio Trinchieri¹ 

[1] Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health

关键词: cancer;    granulopoiesis;    microbiota;    neutrophils;    TAN;   

DOI  :  10.1002/JLB.4RI0418-151R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

The role of the microbiota in many diseases including cancer has gained increasing attention. Paired with this is our expanding appreciation for the heterogeneity of the neutrophil compartment regarding surface marker expression and functionality. In this review, we will discuss the influence of the microbiota on granulopoiesis and consequent activity of neutrophils in cancer. As evidence for this microbiota-neutrophil-cancer axis builds, it exposes new therapeutic targets to improve a cancer patient’s outcome.

【 授权许可】

CC BY