Regulation of immune cell signaling by activated protein C

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Laura D. Healy¹  Rachel A. Rigg³  John H. Griffin¹  Owen J. T. McCarty² 

[1] Department of Molecular Medicine, The Scripps Research Institute;Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University;Department of Biomedical Engineering, Oregon Health and Science University;Division of Hematology and Medical Oncology, School of Medicine, Oregon Health and Science University

关键词: activated protein C;    APC;    EPCR;    Mac-1;    neutrophils;    PAR1;    PAR3;    sepsis;   

DOI  :  10.1002/JLB.3MIR0817-338R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Innate immune cells are an essential part of the host defense response, promoting inflammation through release of proinflammatory cytokines or formation of neutrophil extracellular traps. While these processes are important for defense against infectious agents or injury, aberrant activation potentiates pathologic inflammatory disease. Thus, understanding regulatory mechanisms that limit neutrophil extracellular traps formation and cytokine release is of therapeutic interest for targeting pathologic diseases. Activated protein C is an endogenous serine protease with anticoagulant activity as well as anti-inflammatory and cytoprotective functions, the latter of which are mediated through binding cell surface receptors and inducing intracellular signaling. In this review, we discuss certain leukocyte functions, namely neutrophil extracellular traps formation and cytokine release, and the inhibition of these processes by activated protein C.

【 授权许可】

CC BY