Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis | |
article | |
Eleanor A. Fallon1  Bethany M. Biron-Girard1  Chun-Shiang Chung1  Joanne Lomas-Neira1  Daithi S. Heffernan1  Sean F. Monaghan1  Alfred Ayala1  | |
[1] Division of Surgical Research, Department of Surgery, Rhode Island Hospital, Brown University | |
关键词: immunomodulation; immunosuppression; infection; innate immunity; PD-1; PD-L1; | |
DOI : 10.1002/JLB.2MIR0917-377R | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
Coinhibitory molecules, such as PD-1, CTLA-4, 2B4, and BTLA, are an important new family of mediators in the pathophysiology of severe bacterial and/or fungal infection, as well as the combined insults of shock and sepsis. Further, the expression of these molecules may serve as indicators of the immune status of the septic individual. Using PD-1:PD-L as an example, we discuss in this review how such checkpoint molecules may affect the host response to infection by mediating the balance between effective immune defense and immune-mediated tissue injury. Additionally, we explore how the up-regulation of PD-1 and/or PD-L1 expression on not only adaptive immune cells (e.g., T cells), but also on innate immune cells (e.g., macrophages, monocytes, and neutrophils), as well as nonimmune cells during sepsis and/or shock contributes to functional alterations often with detrimental sequelae.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO202105310000676ZK.pdf | 395KB | download |