PDZ proteins are expressed and regulated in antigen-presenting cells and are targets of influenza A virus

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Dante Barreda¹  Marisa Sánchez-Galindo¹  Jessica López-Flores¹  Karen E. Nava-Castro¹  Karen Bobadilla¹  Alfonso Salgado-Aguayo⁴  Teresa Santos-Mendoza¹ 

[1] Department of Immunology. Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas;Department of Genetics and Molecular Biology, Center of Research and Advanced Studies (CINVESTAV);Cátedras CONACYT;Department of Research in Pulmonary Fibrosis. Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas

关键词: dendritic cells;    Dlg;    immune targets;    influenza NS1 protein;    polarity proteins;    Scribble;   

DOI  :  10.1002/JLB.4AB0517-184R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

In this work, we identified the expression, regulation, and viral targeting of Scribble and Dlg1 in antigen-presenting cells. Scribble and Dlg1 belong to the family of PDZ (postsynaptic density (PSD95), disc large (Dlg), and zonula occludens (ZO-1)) proteins involved in cell polarity. The relevance of PDZ proteins in cellular functions is reinforced by the fact that many viruses interfere with host PDZ-dependent interactions affecting cellular mechanisms thus favoring viral replication. The functions of Scribble and Dlg have been widely studied in polarized cells such as epithelial and neuron cells. However, within the cells of the immune system, their functions have been described only in T and B lymphocytes. Here we demonstrated that Scribble and Dlg1 are differentially expressed during antigen-presenting cell differentiation and dendritic cell maturation.While both Scribble and Dlg1 seem to participate in distinct dendritic cell functions, both are targeted by the viral protein NS1 of influenza A in a PDZ-dependent manner in dendritic cells. Our findings suggest that these proteins might be involved in the mechanisms of innate immunity and/or antigen processing and presentation that can be hijacked by viral pathogens.

【 授权许可】

CC BY