Memory B cell heterogeneity: Remembrance of things past

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Gretchen Harms Pritchard¹  Marion Pepper¹ 

[1] Department of Immunology, University of Washington School of Medicine

关键词: antibody;    germinal center;    IgM;    memory B cells;    T-dependent;   

DOI  :  10.1002/JLB.4MR0517-215R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

B cells that persist for long periods of time after antigen encounter exist as either antibodyproducing plasma cells (long-lived plasma cells, LLPCs) that reside primarily in the bone marrow or rapidly responsive memory B cells (MBCs) that reside in the spleen and circulation. Although LLPCs are thought to be non-responsive to a secondary infection, MBCs respond to subsequent infection through the production of antibody-secreting cells, formation of new germinal centers (GCs), and repopulation of the memory pool. Dogma suggests that MBCs express class-switched, somatically hypermutated BCRs after undergoing a GC reaction. Yet this narrow view of MBCs has been challenged over the years and it is now well recognized that diverse MBC subsets exist in both rodents and humans. Here, we review current thoughts on the phenotypic and functional characteristics of MBCs, focusing on a population of somatically hypermutated, high affinity IgM+ MBCs that are rapidly responsive to a secondary malaria infection.

【 授权许可】

CC BY