Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
Getting TANned: How the tumor microenvironment drives neutrophil recruitment | |
article | |
Shuvasree SenGupta1  Bhagawat C. Subramanian2  Carole A. Parent1  | |
[1] Department of Pharmacology, University of Michigan;Laboratory of Cellular and Molecular Biology, Center for Cancer Research | |
关键词: neutrophils; monocytes/macrophages; chemokines; chemotaxis; signaling cascade; signal transduction; leukocyte tumor interactions; cancer; | |
DOI : 10.1002/JLB.3RI0718-282R | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
The directed migration of neutrophils to sites of injury or infection is mediated by complex networks of chemoattractant-receptor signaling cascades. The recent appreciation of neutrophils as active participants in tumor progression and metastasis has drawn attention to a number of chemokine-receptor systems that may drive their recruitment to tumors. However, the dynamic nature of the tumor microenvironment (TME) along with the phenotypic diversity among tumorassociated neutrophils (TANs) call for a more comprehensive approach to understand neutrophil trafficking to tumors. Here, we review recent advances in understanding how guidance cues underlie neutrophil migration to primary and secondary tumor sites.We also discuss how the presence of other myeloid cells, such as functionally diverse subsets of tumor-associated macrophages (TAMs), can further influence neutrophil accumulation in tumors. Finally, we highlight the importance of hypoxia sensing in localizing TAMs and TANs in the tumor niche and provide a cohesive view on how both myeloid cell types shape TME-associated extracellular matrix organization, which in turn contribute to tumor progression.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO202105310000584ZK.pdf | 605KB | download |