A twist in the ABC: regulation of ABC transporter trafficking and transport by FK506-binding proteins

FEBS Letters

article

Markus Geisler¹  Tamás Hegedűs² 

[1] Department of Biology, University of Fribourg;Department of Biophysics and Radiation Biology, Semmelweis University

关键词: ABC transporters;    ABCB;    CFTR;    chaperon;    FKBP;    FKBP38;    HSP90;    PPIase;    TWD1;   

DOI  :  10.1002/1873-3468.13983

来源: John Wiley & Sons Ltd.

【 摘 要 】

Post-transcriptional regulation of ATP-binding cassette (ABC) proteins has been so far shown to encompass protein phosphorylation, maturation, and ubiquitination. Yet, recent accumulating evidence implicates FK506-binding proteins (FKBPs), a type of peptidylprolyl cis–trans isomerase (PPIase) proteins, in ABC transporter regulation. In this perspective article, we summarize current knowledge on ABC transporter regulation by FKBPs, which seems to be conserved over kingdoms and ABC subfamilies. We uncover striking functional similarities but also differences between regulatory FKBPABC modules in plants and mammals. We dissect a PPIase- and HSP90-dependent and independent impact of FKBPs on ABC biogenesis and transport activity. We propose and discuss a putative new mode of transient ABC transporter regulation by cis–trans isomerization of X-prolyl bonds.

【 授权许可】

Unknown