Self-immunity to antibacterial peptides by ABC transporters

FEBS Letters

article

Sander H.J. Smits¹  Lutz Schmitt¹  Konstantinos Beis³ 

[1] Institute of Biochemistry, Heinrich-Heine-University;Center for Structural Studies, Heinrich-Heine-University;Department of Life Sciences, Imperial College London;Rutherford Appleton Laboratory, Research Complex at Harwell

关键词: ABC transporters;    antibacterial peptides;    bacteriocins;    lantibiotics;    mechanism;    microcin;    multidrug resistance;    self-immunity;    structure;   

DOI  :  10.1002/1873-3468.13953

来源: John Wiley & Sons Ltd.

【 摘 要 】

Bacteria produce under certain stress conditions bacteriocins and microcins that display antibacterial activity against closely related species for survival. Bacteriocins and microcins exert their antibacterial activity by either disrupting the membrane or inhibiting essential intracellular processes of the bacterial target. To this end, they can lyse bacterial membranes and cause subsequent loss of their integrity or nutrients, or hijack membrane receptors for internalisation. Both bacteriocins and microcins are ribosomally synthesised and several are posttranslationally modified, whereas others are not. Such peptides are also toxic to the producer bacteria, which utilise immunity proteins or/and dedicated ATP-binding cassette (ABC) transporters to achieve self-immunity and peptide export. In this review, we discuss the structure and mechanism of self-protection that is conferred by these ABC transporters.

【 授权许可】

Unknown