Sphingolipids controlling ciliary and microvillar function

FEBS Letters

article

Fabian Kaiser¹  Mylene Huebecker¹  Dagmar Wachten¹ 

[1] Institute of Innate Immunity, Medical Faculty, University of Bonn

关键词: cilia;    flagella;    glycosphingolipids;    microvilli;    sphingolipids;   

DOI  :  10.1002/1873-3468.13816

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cilia and microvilli are membrane protrusions that extend from the surface of many different mammalian cell types. Motile cilia or flagella are only found on specialized cells, where they control cell movement or the generation of fluid flow, whereas immotile primary cilia protrude from the surface of almost every mammalian cell to detect and transduce extracellular signals. Despite these differences, all cilia consist of a microtubule core called the axoneme. Microvilli instead contain bundled linear actin filaments and are mainly localized on epithelial cells, where they modulate the absorption of nutrients. Cilia and microvilli constitute subcellular compartments with distinctive lipid and protein repertoires and specialized functions. Here, we summarize the role of sphingolipids in defining the identity and controlling the function of cilia and microvilli in mammalian cells.

【 授权许可】

Unknown