The cytochrome bc 1 complex as an antipathogenic target

FEBS Letters

article

Nicholas Fisher¹  Brigitte Meunier²  Giancarlo A. Biagini³ 

[1] MSU-DOE Plant Research Laboratory, Michigan State University;Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay;Parasitology Department, Research Centre for Drugs & Diagnostics, Liverpool School of Tropical Medicine

关键词: cytochrome bc1;    electron transport;    fungicide;    G143A;    malaria;    QoI/QiI;    resistance;   

DOI  :  10.1002/1873-3468.13868

来源: John Wiley & Sons Ltd.

【 摘 要 】

The cytochrome bc1 complex is a key component of the mitochondrial respiratory chains of many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi responsible for crop diseases and Plasmodium falciparum, which causes human malaria. Cytochrome bc1 is an enzyme that contains two (ubi)quinone/quinol-binding sites, which can be exploited for the development of fungicidal and chemotherapeutic agents. Here, we review recent progress in determination of the structure and mechanism of action of cytochrome bc1, and the associated development of antimicrobial agents (and associated resistance mechanisms) targeting its activity.

【 授权许可】

Unknown