The imitation game: a viral strategy to subvert the complement system

FEBS Letters

article

Palak Agrawal¹  Samriddhi Sharma¹  Pradipta Pal¹  Hina Ojha¹  Jayati Mullick²  Arvind Sahu¹ 

[1] Complement Biology Laboratory, National Centre for Cell Science, S. P. Pune University Campus;ICMR-National Institute of Virology

关键词: CD59;    complement;    herpesvirus;    innate immunity;    pathogenesis;    poxvirus;    RCA;    viral immune evasion;    viral RCA;   

DOI  :  10.1002/1873-3468.13856

来源: John Wiley & Sons Ltd.

【 摘 要 】

Viruses are obligate parasites of cellular hosts and therefore are constantly confronted with the host immune system. Evasion of innate immunity mechanisms by viruses is paramount for the establishment of their infection. The complement system can directly neutralize viruses and also augments adaptive immune responses against them. This system, therefore, is central to host innate immune surveillance, and viruses have evolved a multitude of ways to escape its assault. A major strategy employed by viruses is the molecular mimicry of human complement regulators, namely regulators of complement activation (RCA) proteins and CD59. Herein, we outline up-to-date information on the structure, function and role of viral homologs of the human complement regulators in viral pathogenesis.

【 授权许可】

Unknown