Stress-specific aggregation of proteins in the amyloid bodies

FEBS Letters

article

Dane Marijan¹  Ronnie Tse¹  Keenan Elliott¹  Sahil Chandhok¹  Monica Luo¹  Emma Lacroix¹  Timothy E. Audas¹ 

[1] Department of Molecular Biology and Biochemistry, Simon Fraser University;Centre for Cell Biology, Development, Simon Fraser University

关键词: amyloid aggregation;    cellular stress;    heat shock;    protein aggregation;    subnuclear domains;   

DOI  :  10.1002/1873-3468.13597

来源: John Wiley & Sons Ltd.

【 摘 要 】

Physiological amyloid aggregation occurs within the nuclei of stress-treated cells. These structures, termed Amyloid bodies (A-bodies), assemble through the rapid accumulation of proteins into dense membrane-less organelles, which possess the same biophysical properties as plaques observed in many amyloid-based diseases. Here, we demonstrate that A-body proteomic compositions vary significantly between stimuli, as constituent proteins can be sequestered by one or more stressors. Stimulus exposure alone was insufficient to induce aggregation, demonstrating that this pathway is not regulated solely by stress-induced conformational changes of the A-body targets. We propose that different environmental conditions induce the formation of A-body subtypes containing distinct protein residents. This selective immobilization of proteins may have evolved as a finely tuned mechanism for surviving divergent stressors.

【 授权许可】

Unknown