Preparation for DNA replication: the key to a successful S phase

FEBS Letters

article

Juanita C. Limas¹  Jeanette Gowen Cook¹ 

[1] Department of Pharmacology, University of North Carolina at Chapel Hill;Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill

关键词: cell cycle;    DNA replication;    origin licensing;    genome stability;    replication stress;    checkpoint;   

DOI  :  10.1002/1873-3468.13619

来源: John Wiley & Sons Ltd.

【 摘 要 】

Successful genome duplication is required for cell proliferation and demands extraordinary precision and accuracy. The mechanisms by which cells enter, progress through, and exit S phase are intense areas of focus in the cell cycle and genome stability fields. Key molecular events in the G1 phase of the cell division cycle, especially origin licensing, are essential for pre-establishing conditions for efficient DNA replication during the subsequent S phase. If G1 events are poorly regulated or disordered, then DNA replication can be compromised leading to genome instability, a hallmark of tumorigenesis. Upon entry into S phase, coordinated origin firing and replication progression ensure complete, timely, and precise chromosome replication. Both G1 and S phase progressions are controlled by master cell cycle protein kinases and ubiquitin ligases that govern the activity and abundance of DNA replication factors. In this short review, we describe current understanding and recent developments related to G1 progression and S phase entrance and exit with a particular focus on origin licensing regulation in vertebrates.

【 授权许可】

Unknown