Maintaining order: COG complex controls Golgi trafficking, processing, and sorting

FEBS Letters

article

Jessica B. Blackburn¹  Zinia D'Souza¹  Vladimir V. Lupashin¹ 

[1] Department of Physiology and Biophysics, University of Arkansas for Medical Sciences

关键词: COG complex;    glycosylation;    Golgi;    SNARE;    tethers;    vesicular trafficking;   

DOI  :  10.1002/1873-3468.13570

来源: John Wiley & Sons Ltd.

【 摘 要 】

The conserved oligomeric Golgi (COG) complex, a multisubunit tethering complex of the CATCHR (complexes associated with tethering containing helical rods) family, controls membrane trafficking and ensures Golgi homeostasis by orchestrating retrograde vesicle targeting within the Golgi. In humans, COG defects lead to severe multisystemic diseases known as COGcongenital disorders of glycosylation (COG-CDG). The COG complex both physically and functionally interacts with all classes of molecules maintaining intra-Golgi trafficking, namely SNAREs, SNARE-interacting proteins, Rabs, coiled-coil tethers, and vesicular coats. Here, we review our current knowledge of COG-related trafficking and glycosylation defects in humans and model organisms, and analyze possible scenarios for the molecular mechanism of the COG orchestrated vesicle targeting.

【 授权许可】

Unknown