Form and function of the Golgi apparatus: scaffolds, cytoskeleton and signalling

FEBS Letters

article

Prajakta Kulkarni-Gosavi¹  Christian Makhoul¹  Paul A. Gleeson¹ 

[1] The Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne

关键词: actin;    cell sensing;    Golgi morphology;    Golgi ribbon;    Golgi stacks;    microtubules;    MTOC;    signalling;   

DOI  :  10.1002/1873-3468.13567

来源: John Wiley & Sons Ltd.

【 摘 要 】

In addition to the classical functions of the Golgi in membrane transport and glycosylation, the Golgi apparatus of mammalian cells is now recognised to contribute to the regulation of a range of cellular processes, including mitosis, DNA repair, stress responses, autophagy, apoptosis and inflammation. These processes are often mediated, either directly or indirectly, by membrane scaffold molecules, such as golgins and GRASPs which are located on Golgi membranes. In many cases, these scaffold molecules also link the actin and microtubule cytoskeleton and influence Golgi morphology. An emerging theme is a strong relationship between the morphology of the Golgi and regulation of a variety of signalling pathways. Here, we review the molecular regulation of the morphology of the Golgi, especially the role of the golgins and other scaffolds in the interaction with the microtubule and actin networks. In addition, we discuss the impact of the modulation of the Golgi ribbon in various diseases, such as neurodegeneration and cancer, to the pathology of disease.

【 授权许可】

Unknown