miR-134 inhibits osteosarcoma cell invasion and metastasis through targeting MMP1 and MMP3 invitro and invivo

FEBS Letters

article

Cheng-long Chen¹  Long Zhang²  Yu-rui Jiao¹  Yi Zhou³  Qiao-feng Ge¹  Peng-cui Li⁴  Xiao-juan Sun⁴  Zhi Lv² 

[1] Second Clinical Medical College of Shanxi Medical University;Department of Orthopaedics, Second Hospital of Shanxi Medical University;First Clinical Medical School of Southern Medical University;Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Second Hospital of Shanxi Medical University

关键词: invasion;    matrix metalloproteinases;    metastasis;    miR-134;    osteosarcoma;   

DOI  :  10.1002/1873-3468.13387

来源: John Wiley & Sons Ltd.

【 摘 要 】

miR-134 has been shown to be associated with angiogenesis and the progression of osteosarcoma. This study further assessed the effects of miR-134 expression on osteosarcoma cell migration, invasion, and metastasis in vitro and in a nude mouse xenograft model, exploring the underlying molecular events. Luciferase reporter assays revealed that miR-134 directly targets the 30 -UTRs of MMP1 and MMP3 to reduce their expression in osteosarcoma cells. In conclusion, overexpression of miR-134 suppresses osteosarcoma cell invasion and metastasis through the inhibition of MMP1 and MMP3 expression. We propose miR-134 as an attractive novel therapeutic target for the treatment of osteosarcoma.

【 授权许可】

Unknown