YAPping about and not forgetting TAZ

FEBS Letters

article

Bernard A. Callus¹  Megan L. Finch-Edmondson²  Sue Fletcher¹  Steve D. Wilton¹ 

[1] Centre for Comparative Genomics, Murdoch University;Discipline of Child and Adolescent Health, Children's Hospital at Westmead Clinical School, University of Sydney Medical School;Cerebral Palsy Alliance Research Institute, University of Sydney;Perron Institute for Neurological and Translational Research

关键词: cancer;    cellular localization;    functional regulation;    gene transcription;    Hippo signalling;    phosphodegron;    protein–protein interaction;    stability;    transcriptional coactivator with PDZ-binding motif;    yes-associated protein;   

DOI  :  10.1002/1873-3468.13318

来源: John Wiley & Sons Ltd.

【 摘 要 】

The Hippo pathway has emerged as a major eukaryotic signalling pathway and is increasingly the subject of intense interest, as are the key effectors of canonical Hippo signalling, YES-associated protein (YAP) and TAZ. The Hippo pathway has key roles in diverse biological processes, including network signalling regulation, development, organ growth, tissue repair and regeneration, cancer, stem cell regulation and mechanotransduction. YAP and TAZ are multidomain proteins and function as transcriptional coactivators of key genes to evoke their biological effects. YAP and TAZ interact with numerous partners and their activities are controlled by a complex set of processes. This review provides an overview of Hippo signalling and its role in growth. In particular, the functional domains of YAP and TAZ and the complex mechanisms that regulate their protein stability and activity are discussed. Notably, the similarities and key differences are highlighted between the two paralogues including which partner proteins interact with which functional domains to regulate their activity.

【 授权许可】

Unknown