Ondansetron and Granisetron for Prevention of Postoperative Nausea and Vomiting following Laparoscopic Cholecystectomy

Journal of Nepal Medical Association

article

Sabin Gauchan¹  Chitra Thapa¹  Priyanka Shakya¹  Ramesh Bhattarai¹  Sajal Shakya¹ 

[1] Department of Anesthesia, Nepal Medical College and Teaching Hospital

关键词: Granisetron;    Laparoscopic cholecystectomy;    Ondansetron;    postoperative nausea vomiting.Â;   

DOI  :  10.31729/jnma.2591

学科分类：社会科学、人文和艺术（综合）

来源: Nepal Medical Association since

【 摘 要 】

Introduction: Laparoscopic surgeries are known to be associated with a higher incidence of postoperative nausea and vomiting. Prophylaxis of PONV is usually achieved with a single-dose antiemetic drug administered during the surgical procedure. The aim of this study was to compare the antiemetic efficacy of two different 5-hydroxytryptamine-3 receptor antagonists, ondansetron and granisetron when given prophylactically to patients undergoing laparoscopic cholecystectomy.Methods: It was a randomized, double blind study, conducted in 90 patients. Patients were divided into two groups: Group A and Group B with 45 patients in each group. Patients in groupA were given 100microgram/kg ondansetron intravenously (IV),and patients in Group B were given 40 microgram/kg granisetron. Both the drugs were diluted in 10 ml of 0.9% NaCl and were given at the end of surgery. The standard general anesthetic technique was administered to all the patients. Episodes of nausea, retching and vomiting were assessed during the first 24 hours after anesthesia.Results: There was no statistically significant difference for demographic data and duration of surgery among the two groups (P > 0.05). Evaluated nausea and vomiting scores in the first 3hours period revealed that each of the drugs had a similar antiemetic effect (P > 0.05). Between 4–12 hours also the episodes of nausea, retching as well as vomiting were statistically insignificant in both the groups. In the last 12 hours, episodes of nausea, retching and vomiting were significantly higher in ondansetron group.Conclusions: Granisetron, when given prophylactically, resulted in a significantly lower incidence of PONV than ondansetron in the first 24 hours.

【 授权许可】

CC BY