Diffuse Systemic Sclerosis with Left Ventricular Diastolic Dysfunction: A Case Report

Journal of Nepal Medical Association

article

Asmita Neupane¹  Prabesh Luintel¹  Subodh Sagar Dhakal² 

[1] Kathmandu Medical College and Teaching Hospital, Sinamangal;Department of Internal Medicine, Kathmandu Medical College and Teaching Hospital

关键词: connective tissue disease;    immune-mediated;    rheumatic disease;    scleroderma;    systemic sclerosis.;   

DOI  :  10.31729/jnma.4768

学科分类：社会科学、人文和艺术（综合）

来源: Nepal Medical Association since

【 摘 要 】

Systemic sclerosis is a connective tissue disease characterized by wide-spread vascular lesionsand fibrosis of the skin and internal organs. It is an immune mediated rheumatic disease with thepresence of an immunological dysfunction of T lymphocytes, especially Th1 and Th17 subtypes. Itaffects gastrointestinal, pulmonary, vascular, musculoskeletal, cardiac and various other systems.This disease is rare but has high morbidity and mortality with less known effective management. Wereport a case of 70-year-old female with systemic sclerosis presented with pain along with swellingover multiple joints since 18 months which exacerbated since last 6 months and wound over fingertips since last 2 weeks. We present here other various signs, investigations and management of thisuncommon disease systemic sclerosis, also known as scleroderma. Various systems are evident tobe involved including cardiac (left ventricular diastolic dysfunction) and peripheral vascular system(Raynaud’s phenomenon).

【 授权许可】

CC BY